Nicotinamide CAS NO.98-92-0

Nicotinamide, also known as niacinamide, is a form of vitamin B3 with several advantages, particularly in the realms of skincare, health supplements, and pharmaceutical applications. Here’s a detailed look at its benefits:

1. Skincare

- Anti-Aging: Nicotinamide is known for its anti-aging properties. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and enhance skin texture.
  
- Brightening: It can help to even out skin tone and reduce hyperpigmentation, making it a popular ingredient in products designed to address uneven skin tone and dark spots.

- Anti-Inflammatory: Nicotinamide has anti-inflammatory properties, which can help soothe irritated skin, reduce redness, and manage conditions like acne and rosacea.

- Moisturizing: It helps to strengthen the skin’s barrier function, improving moisture retention and preventing dryness.

- Sun Protection: While not a substitute for sunscreen, nicotinamide can help protect the skin from damage caused by UV exposure and improve the skin’s resilience to environmental stressors.

2. Health Supplements

- Vitamin B3 Supplement: Nicotinamide is a form of vitamin B3, which is essential for various metabolic processes in the body, including energy production and DNA repair.

- Supports Metabolism: It plays a role in converting food into energy by aiding in the function of enzymes involved in metabolic processed

- Skin Health: Beyond topical application, nicotinamide supplements can support overall skin health and help in managing skin conditions from within.

3. Pharmaceutical Applications

- Treatment of Skin Disorders: Nicotinamide is used in the treatment of certain skin conditions, such as acne and dermatitis. It can be incorporated into topical treatments to reduce inflammation and promote healing.

- Potential Neuroprotective Benefits: Research suggests that nicotinamide may have neuroprotective properties and could potentially be used in treatments for neurodegenerative diseases.

 4. Cosmetic Formulations

- Stability: Nicotinamide is stable and can be used effectively in a range of cosmetic formulations without degrading or losing efficacy.

- Compatibility: It is compatible with other common skincare ingredients, including retinoids and hyaluronic acid, making it a versatile addition to many formulations.

 5. Safety and Tolerance

- Well-Tolerated: Nicotinamide is generally well-tolerated by most skin types, including sensitive skin. It is less likely to cause irritation compared to some other active ingredients.

- **Low Risk of Side Effects**: Topical use of nicotinamide has a low risk of side effects, making it a popular choice for those with sensitive or problem-prone skin.

 6. Economic and Practical Benefits

- Cost-Effective: Nicotinamide is relatively inexpensive to produce and incorporate into formulations, making it a cost-effective ingredient for both manufacturers and consumers.

- Versatility: Its wide range of benefits allows it to be used in a variety of products, including serums, moisturizers, sunscreens, and oral supplements.

### Summary

Nicotinamide's advantages are substantial, especially in the fields of skincare and health. Its ability to improve skin texture, reduce signs of aging, and support overall skin health, along with its role as a vital nutrient in the body, make it a valuable ingredient and supplement. Its stability, compatibility with other ingredients, and low risk of side effects further enhance its appeal.

 Nicotinamide (Niacinamide) Product Details

**1. Basic Information:**

- Chemical Name: Nicotinamide
- Alternative Name: Niacinamide, Vitamin B3 (when referring to its broader category)
- Chemical Formula: C?H?N?O
- Molecular Weight: 122.12 g/mol
- CAS Number: 98-92-0

2. Physical Properties:

- **Appearance:** White, crystalline powder or solid
- Odor: Odorless
- Solubility: Soluble in water, ethanol, and glycerin
- Melting Point: Approximately 130-140 °C (266-284 °F)

3. Chemical Properties:

- pH: Nicotinamide is mildly acidic or neutral in aqueous solutions.
- Stability:** Generally stable under normal storage conditions. Sensitive to strong acids and bases.

4. Common Forms and Packaging:

- Powder Form: Available as a white crystalline powder, often packaged in airtight containers to protect from moisture.
- Solutions and Creams: Incorporated into various skincare formulations such as serums, creams, and lotions.
- Capsules/Tablets: Available as dietary supplements in various dosages.

5. Production:

- **Synthetic Production:** Nicotinamide is typically synthesized chemically through the oxidation of nicotine or the reaction of niacin (another form of Vitamin B3) with ammonia.

6. Applications:

- Skincare:
  - Anti-Aging: Reduces fine lines and wrinkles, improves skin elasticity.
  - Brightening: Evens out skin tone and reduces hyperpigmentation.
  - Anti-Inflammatory: Soothes irritated skin and reduces redness.
  - Moisturizing: Strengthens skin barrier function and retains moisture.
  - Sun Protection: Enhances skin’s resistance to UV damage.

- Health Supplements:
  - Vitamin B3 Source: Supports metabolism, energy production, and DNA repair.
  - Skin Health: May aid in managing skin conditions from within.

- Pharmaceuticals:
  - Treatment of Skin Disorders: Used in topical treatments for acne, dermatitis, and other skin conditions.
  - Potential Neuroprotective Benefits: Research suggests possible benefits in neurodegenerative disease management.

- Cosmetics:
  - Stable Ingredient: Maintains efficacy in various formulations.
  - Compatible: Works well with other active skincare ingredients like retinoids and hyaluronic acid.

7. Safety and Handling:

- Toxicity: Nicotinamide is generally considered safe for topical and oral use. Excessive oral intake may cause nausea or liver issues, but such cases are rare with typical dosages.
- Irritation: Topical use is usually well-tolerated, but sensitivity can occur in some individuals. It is advised to perform a patch test before extensive use.
- Storage: Store in a cool, dry place, away from moisture and strong light. For formulations, follow specific product storage instructions.

8. Environmental and Regulatory Information:

- Disposal: Nicotinamide should be disposed of according to local regulations. It is not classified as hazardous waste.
- Labels: Products containing nicotinamide should include clear labeling and safety data sheets (SDS) with handling instructions.

9. Economic and Practical Considerations:

- Cost-Effectiveness: Nicotinamide is relatively affordable, making it a cost-effective choice for both manufacturers and consumers.
- Versatility: Its benefits extend across skincare, health supplements, and pharmaceuticals, allowing it to be used in a wide range of products.

### Summary

Nicotinamide (niacinamide) is a valuable compound in skincare and health, known for its stability, versatility, and multiple benefits. Its uses range from improving skin appearance and treating various skin conditions to supporting overall health as a dietary supplement. Its safe profile, coupled with its cost-effectiveness, makes it a popular ingredient in many formulations.